The kidneys have a vital role in continuously clearing toxins from the body. AKI is a common clinical syndrome in which the kidneys stop working properly. It affects up to 1 in 5 people in hospital, usually as a complication of a severe illness or major surgery. 1 in 3 people with AKI experience it recurrently. Researchers highlight multiple missed opportunities in optimising continuing care after hospital discharge.

Funded by the National Institute for Health and Care Research (NIHR) and supported by the NIHR Patient Safety Research Collaboration (PSRC): Greater Manchester this is the first major investigation of post-discharge care for people with AKI to cover widespread care in general practices (GPs) across England. The study was published in today (12 August).

Researchers analysed the healthcare of more than 209,000 patients in England who had been discharged from hospital after an episode of acute kidney injury (AKI), using records from over 1,400 general practices (GPs). They found that the recommended clinical guidelines for continued follow-up care were often not followed, suggesting that AKI is not receiving sufficient attention at handover from hospitals to primary care.

Why follow-up care after AKI matters

Even after hospital discharge, people who have had AKI remain at a high risk of poor outcomes, including emergency hospital readmission, recurrent AKI and other acute severe illnesses, the development of lasting chronic kidney disease, and major adverse cardiovascular events.

Current recommendations are that when a patient who has experienced AKI is discharged from hospital back into the community, primary care should have a central role in supporting recovery, ensuring safe follow-up, and minimising the risk of worsening health. However, the study identified multiple gaps in post-AKI care as patients transition across care settings.

In the study, only 19% of hospital AKI episodes were documented in primary care records within 30 days of discharge using the recommended codes for AKI. The proportion was even smaller among people aged under 60 years and those who had major surgery.

The study evaluated not just documentation, but also clincal action. Despite regular contact with primary care healthcare professionals, many people did not receive simple recommended blood and urine tests to assess kidney health. Younger individuals and those without already known and documented health concerns were least likely to receive tests. Yet, these are often people who stand most to gain, because early action can help prevent avoidable health problems being stored up into the future.

The study concluded that improvements in the sharing of discharge information and follow-up after AKI could help identify people at risk sooner and improve outcomes for those transitioning from hospital to community care.

, GP and Professor of Primary Care at ����Vlog�ٷ� and NIHR Greater Manchester PSRC, said: “Despite a decade of improvement initiatives in the UK, little was known about how closely primary care follows clinical guidelines after an episode of acute kidney injury.

Our study highlights the urgent need to implement kidney health strategies more effectively across both primary and secondary care. Improving post-AKI care requires greater adoption of a ‘kidney mindset’ and better integration of kidney health into existing services, helping to improve outcomes for patients transitioning from hospital to community care.”

Prof director of the NIHR Greater Manchester PSRC, said: “Patient safety depends on delivering the right care at the right time, particularly during transitions between healthcare settings. This study highlights significant opportunities to strengthen the follow-up care offered to patients after AKI, providing valuable evidence to inform future improvements in care for this population.”

Key recommendations for strengthening post-discharge care for AKI patients:

• Improve communication and sharing of information at discharge, to ensure that arrangements for follow-up care after AKI do not become lost during transition across care settings.
• Strengthen the implementation of kidney health strategies across primary and secondary care, including clear discharge arrangements and case-specific guidance on discharge summaries.
• Better resource these implementation strategies to strengthen follow-up care across multiple areas, such as early and ongoing patient engagement; coordination across care interfaces; and protocols to ensure clear delegation of responsibilities.
• Improve the identification and monitoring of kidney disease after AKI, including routine recording of AKI diagnoses and recommended blood and urine tests.

Podcast recommendation – Lost in Transition: How Care Gaps Impact Patient Safety

Transitions in care are high-risk moments for patient safety, whether from hospital to home, mental health settings to the community, or between healthcare services. An episode of the Voices for Safety podcast explored research insights into how to make transitions across care settings safer for patients. Prof Tom Blakeman, co-author of this post-discharge AKI study, is one of the guests in this special episode, sharing insights into AKI follow-up care.

The paper Examining variations in adherence to guideline-recommended post-acute kidney injury care in primary care in England: A population-based cohort study, published in BMC Medicine, is available at

Publication details

The study was published in the Journal of Sex Research.

DOI: .

Key findings

• AI adoption is heavily concentrated in London, the South East and larger businesses, meaning its economic benefits could reinforce existing regional and productivity inequalities

• The country lacks the computing and energy infrastructure needed to deliver the Government’s ambitions, which could consume more than a quarter of the UK’s electricity

• Poor-quality, fragmented data and outdated IT systems could hamper AI adoption across government

• Skills shortages are holding back AI adoption, particularly among smaller businesses and in the public sector, despite years of government investment in digital skills

• AI is not a ‘magic bullet’ for Britain’s economic and public-service problems, and rapid expansion could create new environmental, social and governance risks

Unequal benefits and risks

Researchers Nathan Critch and Darcy Luke say years of short-term and fragmented policymaking by successive governments have left the UK with significant infrastructure and capacity gaps which could undermine Labour’s plans.

The Government’s AI Opportunities Action Plan includes plans to increase UK AI computing capacity twentyfold by 2030, develop AI Growth Zones, establish a National Data Library and expand the use of AI across government and the wider economy.

The researchers warn that the benefits of AI are unlikely to be shared evenly across the UK without policies specifically designed to encourage wider adoption.

Only 15% of UK businesses had adopted at least one AI technology in 2022, with adoption particularly concentrated among larger companies. AI adoption was highest in IT and telecommunications and legal services, while it was much lower in hospitality, health and retail - sectors which employ large numbers of people.

AI firms and businesses using AI are also heavily concentrated in London and the South East.

The study argues that this creates a risk that AI will make already productive businesses and regions even more productive, while areas and sectors which have struggled with low productivity are left further behind.

UK lacks infrastructure for AI boom

The UK currently has only around 3% of the world’s computational power - much of which is not optimised for AI - leaving the country dependent on cloud computing provided by large technology companies.

The researchers warn that expanding computing capacity will place enormous demands on the UK’s energy infrastructure. They estimate that a twentyfold increase in UK computing capacity could increase the energy consumed by AI infrastructure from around 3.6 terawatt-hours (TWh) in 2020 to 72 TWh – more than a quarter of the UK’s total electricity consumption.

This creates a tension between the Government’s AI ambitions and its commitment to reaching net zero, particularly given constraints in the electricity grid and limited energy storage capacity. The researchers also highlight the water required to cool data centres as a potential environmental constraint.

Poor data and outdated technology

The study identifies the quality and accessibility of government data as another major obstacle. A National Audit Office survey found that 62% of responding government bodies identified a lack of access to good-quality data as a major barrier to implementing AI. Government data is often held in fragmented systems and legacy IT infrastructure, while data held by local authorities can be siloed across incompatible systems.

The researchers argue that these problems will make it difficult to deliver the Government’s plans for AI-enabled public services without significant investment in underlying digital infrastructure. They also warn that the public sector faces persistent digital skills shortages, with problems particularly acute in local government.

Skills shortages could limit AI adoption

Despite a relatively strong range of AI-related training in the UK, demand for AI skills continues to outstrip supply.

Smaller businesses are particularly disadvantaged because larger companies can offer higher salaries and attract workers with scarce AI expertise. The researchers also highlight a lack of in-work training, vocational education and further education provision compared with the emphasis placed on higher education.

These problems could limit the Government’s ambitions to use AI to improve productivity across the economy and make public services more efficient.

Decade of AI policy leaves UK with major gaps

The researchers argue that Labour’s approach is part of almost a decade of increasingly active government policy on AI, stretching back through the Conservative governments of Theresa May, Boris Johnson and Rishi Sunak. They describe this pattern as “hyperactive incrementalism” - characterised by short-termism, fragmentation, limited evaluation and repeated policy initiatives.

While the UK has developed an internationally significant AI sector, the researchers say this should not be confused with widespread adoption of AI across the economy.

Successive governments have focused heavily on developing the UK’s AI sector, they argue, but have been less successful at encouraging businesses and public services across the country to adopt AI. The result is a significant gap between the Government’s ambitions for AI and the infrastructure, skills and organisational capacity needed to deliver them.

AI is not a ‘magic bullet’

The researchers argue that there is currently little evidence that AI can, by itself, deliver the broad improvements in productivity, government efficiency and public services envisaged by policymakers.

They also warn that rapid AI expansion could create new problems, including threats to data protection and civil liberties, surveillance, deskilling and unemployment, and increased environmental pressures.

What the researchers say

“AI adoption is currently concentrated in the businesses, sectors and regions that are already among the most productive,” said Darcy Luke from The University of Edinburgh’s BRAID (Bridging Responsible AI Divides) Research Programme. “Without policies that encourage much wider adoption, there is a real risk that AI will reinforce existing inequalities rather than reduce them.”

The researchers conclude that while Labour’s plans represent the most comprehensive attempt by a UK Government to harness AI, the scale and depth of the barriers involved mean that AI may ultimately become “another problem for an already problem-laden government, rather than the solution it is hoped to be.”

Publication details

The paper was published in the journal The Political Quarterly.

DOI:

The Mental Health Digital Innovation (MHDI) workstream has been launched as one arm of the UK Government’s Mental Health Goals Programme as a new national initiative designed to accelerate the infrastructure and development to support adoption of digital technologies that improve mental health outcomes across the UK.

Despite rapid advances in digital technologies, many promising mental health tools struggle to move beyond pilot projects and achieve widespread adoption. Fragmented infrastructure, complex procurement processes, lack of demand signalling, unclear reimbursement pathways and limited coordination between stakeholders have created significant barriers to innovation reaching patients and services at scale. MHDI has been established to build practical pathways that help digital innovations move from development and evaluation into routine care.

brings together people with lived experience of mental health problems, clinicians, industry partners, innovators, researchers and investors to create a more connected and effective ecosystem for digital mental health innovation.

The MHDI workstream is being led by the University of Manchester, with workstream leads Professor Pauline Whelan (University of Manchester, CareLoop Health Ltd) and Dr Trina Histon (Director of Percolating Health) who will work closely with partners: H, (MH-TRC), , NHS organisations, academic institutions, industry partners and people with lived experience of mental health conditions.

MHDI's mission is to make it easier to design, test, adopt and scale digital mental health technologies across the UK.

The initiative will support a broad range of innovations, including digital technologies, digital mental health interventions, digital therapeutics, remote monitoring tools, data-driven decision support systems, wearable technologies and emerging approaches that can improve mental health care and research.

Central to MHDI's approach is the belief that people with lived experience of mental health conditions must be involved throughout the innovation pathway. By creating stronger partnerships between service users, industry, researchers and healthcare providers, MHDI aims to ensure future digital solutions are both clinically effective and meaningful to the people who use them.

The programme will focus on:

• Developing user-centred, industry-aligned digital infrastructure and services.
• Creating clearer pathways for procurement, reimbursement and implementation.
• Supporting NHS organisations through practical implementation guidance and digital navigation support.
• Accelerating the adoption of proven technologies across health services.
• Encouraging sustainable investment models that combine public and private sector support.
• Strengthening the UK's position as a global leader in digital mental health innovation.

For innovators, MHDI will help simplify engagement with the NHS by improving access to guidance, partnerships, investment opportunities and routes to scale.

For NHS organisations and clinical teams, the initiative will promote coordinated national support, reduce duplication of effort and provide practical assistance for adopting new technologies effectively.

For people and communities, MHDI will ensure that more high-quality digital mental health solutions reach those who need them, are easier to access and are better integrated into care pathways.

The initiative has been shaped by extensive engagement with stakeholders and recommendations emerging from national workshops on digital mental health implementation. These recommendations highlight the need for a clear national digital mental health strategy, stronger integration of lived experience, enhanced evaluation approaches and greater support for workforce capability.

By creating clearer pathways for adoption and fostering collaboration across sectors, MHDI aims to remove longstanding barriers to innovation and help establish the UK as a leading destination for digital mental health research, development and implementation.

For more information and future updates on Mental Health Digital Innovation, visit the MHDI or follow on LinkedIn.

, the research addresses a long-standing challenge in chemistry: developing biological catalysts that can selectively construct complex molecular architectures. Carbon-carbon and carbon-nitrogen bonds are fundamental building blocks in many chemicals, pharmaceuticals and advanced materials.

To expand upon the reaction pathways found in natural enzymes, the researchers engineered proteins containing a non-natural catalytic amino acid. This facilitated the development of a new enzyme class, termed allylic transferases, which form highly reactive imidazolium intermediates that could then be intercepted by a variety of carbon- and nitrogen-containing molecules, selectively producing a diverse range of products.

The team used directed evolution to improve enzyme performance. One evolved variant, known as ASB1.3, achieved more than 99% conversion in several reactions while delivering products with high stereochemical purity. In a preparative-scale reaction, the enzyme produced the target compound with 98% conversion.

A second enzyme variant, ASA1.5, enabled the formation of molecules containing all-carbon quaternary stereocentres, structures that can be challenging to synthesise selectively. In preparative-scale experiments, the enzyme achieved 98% conversion.

The researchers demonstrated that the engineered enzymes could work with a broad range of reaction partners, including substituted furans, indoles, pyrroles, cyanoesters, diketones, ketoesters, anilines and isatins. Across the reactions examined, the enzymes generated a single major product with no observable by-products other than the released leaving group used for monitoring the reaction.

Expanding the biocatalysis toolbox

Structural analysis also provided new insights into how the enzymes achieve their selectivity. The team found evidence that a para-nitrophenol group released during the reaction remains in the enzyme active site and helps orient incoming reactants, contributing to stereoselective bond formation.

While further development will be needed before these enzymes can be applied more widely, the study expands the range of chemical transformations available through biocatalysis. The study highlights how engineered protein catalysts can provide new ways to access molecular structures that are difficult to produce using established small-molecule catalysts.

First author Zachary Birch-Price said:

Key findings

• Urban canals reduce daytime temperatures by an average of around 0.8°C within their immediate surroundings, typically 20–50 metres away from the water
• Cooling is strongest during spring and early summer, reaching around 1.2–1.4°C
• During heatwaves, canals can lower nearby temperatures by 1.5–2.3°C
• The cooling effect substantially reduced the number of hours when people in the vicinity of canals would experience moderate and high heat stress
• Around 6.2 million people live within one kilometre of Britain's urban canal network, meaning millions could potentially benefit from these cooling effects

Using a new energy balance model, developed by researchers in the Geography, Planning and Engineering departments, the research simulated the thermal behaviour of more than 2,300 canal sections across Great Britain and Ireland over an entire year.

The researchers found that while canals produce a small warming effect overnight because water retains heat longer than surrounding surfaces, this effect is relatively minor compared with the cooling benefits during the day.

Improving health and wellbeing

The researchers also assessed how canals affect thermal comfort during hot weather.

Their modelling showed that incorporating the cooling effect of canals reduced the number of hours classified as posing moderate heat risk by around 58%, while hours of high heat risk fell by around 74%. In many locations, canals eliminated periods of extreme heat risk altogether, although the researchers caution that this is partly counter-balanced by rising humidity, which also influences people's comfort during hot weather.

The findings suggest canals could help reduce heat-related illness, improve wellbeing and encourage people to stay active and walk and cycle during hotter weather, in turn allowing access to nature and reducing carbon emissions through active transport.

"As climate change makes heatwaves more frequent and intense, cities need every available tool to help people stay safe and comfortable,” said lead author Dr Matt Tomkins. “Our research shows that canals, which were originally built to power the Industrial Revolution, could now play an important role in helping cities adapt to climate change.”

"The cooling effect is modest on an average day, but during heatwaves it becomes much more significant, reducing nearby temperatures by more than two degrees in some locations. Even relatively small reductions like these can make an important difference to people's health and wellbeing during periods of extreme heat."

Supporting climate-resilient cities

The researchers say that alongside urban heat regulating services, which have been estimated to provide economic benefits of by reducing losses in labour productivity caused by hot days, the studied canals could play a role in reducing carbon emissions, both through enabling active transport during hotter periods and potentially reducing the demand for energy-intensive air-conditioning.

“Accessible blue and green spaces result in wider health and wellbeing benefits for society” says co-author Dr. Joanne Tippett. “The cooling that canals offer could help more people to stay active and access these spaces even during hot days. This highlights the importance of not only protecting our urban canals, but also thinking about how to increase signposting and access, connectivity with other green infrastructure, and wider awareness of these vital networks of urban cooling”.

They emphasise that canals are not a complete solution to rising urban temperatures, but argue they should form part of a wider package of climate adaptation measures alongside parks, trees, sustainable drainage and other forms of green and blue infrastructure.

The study also provides a new modelling approach that could be applied more widely to assess how similar waterways contribute to cooling in other cities around the world, and to complement insights gained from field-based measurements, modelling, and satellite-based observations.

Publication details

The study was published in Nature Communications.

Funding, data, and support for this project was provided by the Canal and River Trust, with the research generously supported thanks to funds raised by Postcode Lottery players.

DOI:

Building on more than a decade of success, brings together five leading northern universities to support healthcare professionals to become the next generation of research leaders.

Director of Forward North Professor from the University of Manchester, said: "I am delighted that we can continue to offer doctoral training fellowships for healthcare professionals over the next five years.

“By working together across the North, we can help more healthcare staff develop research careers and generate the discoveries and innovations needed to improve patient care and health outcomes."

The renewed programme builds on a strong track record of supporting healthcare professionals to undertake PhDs.

It will also introduce new pre-doctoral opportunities to help more people enter research, provide enhanced support for early career researchers, and strengthen partnerships with organisations including the Nuffield Foundation, STEM Learning and the Francis Crick Institute.

Through expert mentoring, interdisciplinary collaboration, industry engagement and specialist training, Forward North will help develop future research leaders equipped to tackle some of the North's biggest health challenges.

A virtual launch event will take place on 18 August from 11.30am to 1pm, providing information about the next round of fellowship applications and an opportunity to ask questions.

You can join the event

The researchers analysing the records of more than 1.4 million people found that social prescribing – where patients are referred to support such as community groups, exercise schemes or financial advice – was linked to an early rise in healthcare use, followed by a small drop in GP appointments.

The study was funded by the National Institute for Health and Care Research (NIHR) and published in eClinical Medicine.

Social prescribing became a key part of NHS plans in 2019, with thousands of link workers recruited across England to connect patients with community support.

It has become a central part of NHS efforts to address the wider social factors that influence health, including loneliness, housing problems, debt and inactivity.

Despite the scheme's rapid expansion, until now there has been little robust evidence showing whether social prescribing affects NHS demand, healthcare use or costs.

The findings come from one of the largest studies of its kind, using anonymised NHS records from the Clinical Practice Research Datalink (CPRD), covering around a quarter of England’s population.

The research team compared 168,699 patients referred to social prescribing between July 2019 and April 2022 with more than 1.3 million similar patients who were not referred.

In the first six months after referral, patients receiving social prescribing had an average of 2.25 more contacts with healthcare services than those who were not referred – a rise of around 24%.

The increase was largely driven by more visits to primary care services and attendance at planned outpatient appointments in hospitals.

This, they say, may reflect patients becoming more proactive about managing their health and seeking help for conditions that might previously have gone untreated.

But by one year after referral, the picture had changed.

The increase in healthcare contacts had fallen substantially and patients referred to social prescribing were attending slightly fewer GP appointments than those who had not been referred.

Despite the higher number of healthcare interactions, the overall cost to the NHS was virtually unchanged.

The study found healthcare costs were less than 0.1% higher among referred patients, a difference researchers described as clinically insignificant.

The small increase in spending was mainly linked to additional secondary care admissions.

Lead author from ����Vlog�ٷ� said: “Our findings suggest that social prescribing may encourage people to engage with healthcare services in the short term, particularly with planned and preventative care.”

“Importantly, we found that this increase did not translate into meaningful increases in overall healthcare costs, and by one year patients were having slightly fewer GP appointments.”

“This could indicate that social prescribing helps direct people towards more appropriate forms of support while reducing pressure on general practice.”

She added: “Better integration between social prescribing data systems and electronic health records will be needed to understand whether patients who fully engage with these services gain even greater benefits.”

Charlotte Osborn-Forde , CEO of the National Academy for Social Prescribing added: "There is now strong evidence that social prescribing leads to improved wellbeing and that it can support people with a range of health conditions.

"This research provides useful analysis of how referrals to link workers affected healthcare use during the COVID pandemic, potentially leading to a long-term fall in GP appointments.

"It also shows the need for further exploration of how to account for the unmeasured social needs that lead to a referral for social prescribing, and better data on support received after the referral, to track the impact of social prescribing more robustly."

• The paper "Changes in healthcare use and cost associated with referrals to social prescribing link workers in England: a matched case-control cohort study” is published in eClinical Medicine. DOI

Mitochondria provide the energy that cells need to function. Mutations in their DNA can cause serious, progressive conditions affecting organs and tissues with high energy demands, including the brain, heart and muscles. Around one in 5,000 people is affected by a mitochondrial disease, and there is currently no cure.

The Manchester team, led by Sarah Lovelock, Professor of Biological Chemistry in the Department of Chemistry and the Manchester Institute of Biotechnology, will combine genome mining, computational enzyme design and laboratory evolution to develop next-generation base editing tools capable of selectively targeting the most common disease-causing mutations in mitochondrial DNA.

Led by the University of Cambridge, the centre includes partners at the universities of Birmingham, Manchester, Heidelberg and Queensland, the Imagine Institute in Paris, patient charity The Lily Foundation and industry organisations worldwide.

By bringing together academic, clinical, patient and industry perspectives, the centre aims to establish a long-term research platform that can define the causes of mitochondrial disease and accelerate progress towards therapies.

And opening windows during hot weather, they show, almost certainly exacerbates the problem of indoor air pollution caused by the fires.

The University’s Canalysed real time indoor air-quality records from 23 Greater Manchester homes monitored between 1 and 26 July 2026, during two periods of wildfire activity in the nearby Pennine hills.

Every monitored home in the Cystic Fibrosis Trust funded study exceeded the World Health Organization’s 24-hour guideline for fine particle pollution on 17 July, when outdoor smoke levels peaked.

The preliminary analysis, which has not yet undergone peer review, also showed when households opened widows as temperatures climbed to over 33C , the problem seemed to get worse.

, based at ����Vlog�ٷ� and the National Centre for Atmospheric Science (NCAS), led the analysis of PM2.5, particles produced by smoke small enough to travel deep into the lungs, where they can harm health.

During the wildfires, overnight bedroom PM2.5 spiked from an average of 2.7 micrograms per cubic metre to 7.8 with windows closed and 11.8 with windows open. Closing windows reduced exposure, but levels remained 2–4 times higher than normal.

In some homes, concentrations in the bedroom overnight rose to well over 100 micrograms per cubic metre, many times higher than the levels normally recorded in those homes.

Levels of indoor-generated pollution, such as volatile organic compounds and carbon dioxide, actually fell during this period as participants opened windows to cool their homes, allowing the outdoor pollution in.

The researchers say that following the UK Health Security Agency’s guidance on wildfire smoke by staying indoors and closing windows should help reduce the pollution.

Levels, they say, did not rise as much in homes where windows appear to have remained closed though this did not prevent all outdoor smoke pollution from getting in.

The researchers are also currently working on a Greater Manchester Local Innovation Partnership funded study, the Retrofit Advanced Materials and Manufacturing Innovation Centre to investigate measures that may help further combat indoor pollution, for example during periods of wildfire, and during intensely hot weather.

That could include the use of air purification and integrated ventilation systems, improved sleeping arrangements and other measures.

One of the researchers from ����Vlog�ٷ�, said: “These findings show the difficult challenges that people face during periods of wildfires and high environmental temperatures.

“Following the simple but often repeated instruction of going indoors and shutting the windows will only give you some protection from wildfire smoke, and keeps heat in the home. Both smoke and heat can make breathing worse for those with chronic lung conditions.

“During July’s fires, in every home we monitored we found the effects of smoke was present indoors at potentially harmful concentrations levels, especially during periods when the heat forced people to open windows.

“We saw this in homes up to 60km away from the wildfires on the moors outside Manchester.”

, lead Environmental researcher for the group said: “The findings support advice to close windows while smoke levels are high, but show that this cannot completely prevent smoke infiltration and may increase the risk of overheating.

“The challenge is that this advice can be difficult to follow during very hot weather, particularly in homes that are prone to overheating.

“We need clearer, evidence-based guidance that helps households reduce exposure to both smoke and heat. I hope this new data can support these decisions.

“We are now investigating practical measures, including air filtration and approaches to keeping homes cool, so that people - especially those with existing respiratory conditions - have better options during future extreme events such as these.”

Dr Bannan added: “Wildfire smoke contains tiny particles and gases that can irritate the lungs and make respiratory conditions such as cystic fibrosis, asthma and COPD worse.

“Exposure to wildfire smoke can increase symptoms including coughing, wheezing, breathlessness and chest tightness, and may trigger severe flare-ups that require medical treatment.

“That is why people with existing respiratory diseases as well as children, older people and other immunocompromised people are also at greater risk of respiratory infections, hospitalisation and other serious health complications during wildfire events.”

Dr Sharon Weinberg, a clinical research fellow at ����Vlog�ٷ� added:

said: “While our study examines the impact of PM2.5 on lung health, poor air quality affects far more than the lungs.

“Elevated PM2.5 exposure is known to increase the risk of cardiovascular events—including heart attacks, strokes, and thrombosis.

“It is also associated with headaches and migraines, highlighting that the health consequences of air pollution extend well beyond people with chronic respiratory disease.”

Laura Beattie, who has cystic fibrosis and is taking part in the study, said: “I found it really hard during the heatwave and the wildfires.

“You could see and smell the smoke for days, and it made my breathing worse. I was more breathless, and had to restrict myself to staying indoors. I also noticed that my sputum went dark from the smoke - I've never seen it like this before.

“We can all see wildfires becoming more common, and research like this is so important for people like me with chronic lung conditions.”

• The is still recruiting people with CF across the UK, including in the Manchester and Merseyside regions where the air quality monitoring is included as an optional part of the study. The Pulse-CF Innovation Hub is part of the Translational Innovation Hub Network for CF Lung Health & Infection, funded by Cystic Fibrosis Trust and LifeArc. Though these findings are not yet peer reviewed, the research team felt it was in the public interest to release the figures.

The day began with an energetic introduction to chemistry as pupils designed, decorated and built their own Berocca rockets. Using water bottles, water and Berocca tablets, they created rockets powered by the build-up of gas from a simple chemical reaction. After proudly showing off their colourful designs, the pupils launched their creations on the playground, with some soaring to impressive heights of around 10 metres. The excitement and anticipation before each launch made for a fantastic start to the day.

Next, the pupils explored the fascinating behaviour of liquids by creating colourful lava lamps using oil, water, food colouring and salt. As the salt carried coloured water through the oil before sinking to the bottom, the children observed how differences in density produce the characteristic "lava lamp" effect. It was a simple yet captivating experiment that encouraged pupils to think about the science behind everyday phenomena.

In the afternoon, the pupils split into groups, with each group carrying out one of three different experiments. One group built scribble bots using an electric motor, a cork and marker pens. The vibrations from the off-centre cork caused the robots to move unpredictably across the paper, producing unique works of art while introducing the principles of electric motors and engineering design.

Another group investigated the electrical properties of graphite by drawing pictures with pencil and using the graphite lines to complete an electrical circuit. This activity was especially meaningful for us as researchers from the National Graphene Institute, demonstrating how graphite—and its remarkable single-layer form, graphene—can conduct electricity. The pupils also experimented with creating simple fruit batteries, using different fruits to generate enough electrical energy to power the circuit and illustrating how chemical reactions can be converted into electricity.

The final group carried out the ever-popular magic milk experiment. By adding food colouring to whole milk before introducing a drop of washing-up liquid, they watched vibrant colours swirl and dance across the surface. The striking visual effect provided an engaging demonstration of surface tension and molecular interactions.

To finish the day, the pupils took part in a careers fair with a difference. Each group presented the experiment they had completed to their classmates as they visited the different stalls, explaining the science behind their activity and answering questions from their peers. It was wonderful to see the pupils confidently communicate scientific ideas and take pride in what they had learned.

The enthusiasm, curiosity and confidence shown throughout the day were a reminder of the importance of science outreach. We hope the activities inspired the pupils to continue asking questions about the world around them and perhaps even sparked an interest in future careers in science and engineering. It was a privilege to represent the National Graphene Institute and share our passion for scientific discovery with the next generation.

Attendees

• Adam Rosillo (author/CDT student)
• Lucy Kendall (CDT student)
• Helena Amos (CDT student)
• Qian Guo (Postdoctoral Research Associate).

Collecting rainwater from rooftops and using it to spray buildings during hot weather could help cities cut air conditioning use, lower urban temperatures and lessen the impact of heatwaves, according to new research from ����Vlog�ٷ�.

Cities around the world are facing rising temperatures, putting pressure on public health, infrastructure and energy systems. As people rely more on air conditioning to stay cool, energy demand increases and waste heat released from buildings can make urban areas even hotter.

Urban watering technologies are becoming important ways for reducing extreme heat in cities, but their use is often limited by the availability of water.

How does rainwater keep cities cool?

In the study, published in , researchers used process-based numerical simulations and Artificial Intelligence (AI) to test a system that stores rainwater collected from rooftops and automatically sprays it onto buildings during hot weather.

Using Tokyo as their case study, they found that cooling rooftops, the system reduced the amount of energy needed for air conditioning. The cooler roofs transferred less heat into buildings, while lower air conditioning use meant less waste heat was released into the city. Together, these effects helped reduce urban temperatures, cutting the number of heatwave days overall and lessening the intensity of extreme heat events.

What do the reserchers say?

Lead author Dr Zhonghua Zheng, Co-Lead for Environmental Data Science & AI at Manchester Environmental Research Institute (MERI) and Senior Lecturer (Associate Professor) in Data Science and Environmental Analytics at ����Vlog�ٷ�, said: "Cities around the world are facing growing challenges from extreme heat. Air conditioning can help keep people safe and comfortable, but it also consumes large amounts of energy and releases additional heat into the urban environment.

"Our study shows that harvesting rainwater from roofs and using it strategically for cooling could provide a practical way to reduce both energy demand and urban temperatures.

"What is particularly encouraging is that the benefits become even greater during hotter years, suggesting this approach could become increasingly important as the climate continues to warm.”

How would the rainwater sprinklers work?

The study suggests that when the sprinklers switched on - for example, when the roof reached a certain temperature - had a greater impact than either the size of the tank or the amount of water applied. The researchers also found that bigger is not always better. Very large tanks delivered only modest additional reductions in energy use and extreme heat, while applying extra water did not always lead to more cooling because some of it remained on the roof instead of evaporating.

The researchers say the approach could help local authorities and urban planners evaluate how rainwater-based cooling systems might work in their own regions while balancing practical considerations such as cost, water availability and local regulations.

Can rainwater cooling help with other urban challenges?

As cities continue to grapple with rising temperatures, the team believes roof-based rainwater cooling systems could form part of a wider suite of urban climate adaptation measures designed to improve resilience and protect public health.

Junjie Yu, PhD researcher at ����Vlog�ٷ�, added: “The rainwater tank also provides an additional co-benefit on reducing the extreme urban runoff. This approach exemplifies a ‘natural solution to natural challenges’, in which rainwater serves as a natural resource to mitigate both thermal stress and hydrological extremes.”

Published in on 5 August, the University of Manchester and University of ����Vlog�ٷ�icut team has revealed how a little-known protein helps keep one of the body's most powerful biological signals under tight control.

Their findings could eventually help researchers develop new ways to tackle conditions linked to fibrosis, a process in which excessive scar tissue forms in organs and prevents them from working properly.

Fibrosis can affect the lungs, liver, kidneys and other organs, and is thought to contribute to millions of deaths worldwide each year.

At the centre of the discovery is a signalling molecule called transforming growth factor beta, or TGFβ.

This molecule plays a vital role in the body, helping cells grow, communicate with each other, respond to injury and repair damaged tissue.

However, when there is too much active TGFβ it can trigger the build-up of scar tissue, contributing to a range of serious diseases.

Because of its powerful effects, the body normally keeps TGFβ locked away in an inactive state until it is needed.

They used advanced imaging, called cryo-electron microscopy, engineered human cell lines and 3 dimensional�� computer simulations to reveal how a key protein regulates TGFβ activity.

The study revealed for the first time how a protein known as latent TGFβ-binding protein 1, or LTBP1, helps build and stabilise this storage complex.

The researchers discovered that LTBP1 does far more than simply hold TGFβ in place.

Instead, it acts as a key regulator, helping to keep the molecule safely stored while also influencing how it is released.

The team showed how LTBP1 forms a crucial connection with TGFβ and helps determine how much physical force is needed before the signalling molecule can become active.

This mechanical control system ensures that TGFβ is only switched on in the right place and at the right time.

The findings provide an important new understanding of how the body regulates one of its most influential signalling pathways.

The scientists believe the work could help guide future efforts to develop treatments that selectively control TGFβ activity in disease.

Lead author Professor Clair Baldock from ����Vlog�ٷ� said: “TGFβ is one of the body's most important signalling molecules because it influences how cells grow, communicate and repair tissue.

“But when its activity is not properly controlled, it can contribute to diseases such as fibrosis, where excessive scar tissue damages healthy organs.

“Our study has revealed in unprecedented detail how LTBP1 helps store and regulate TGFβ, and how the structure of this protein complex affects the forces needed to activate it.

“By understanding this process more clearly, we have uncovered a new layer of biological control that could help researchers develop more precise therapies in the future.”

“We�� hope our discovery will provide a foundation for future studies aimed at preventing harmful scarring while preserving the body's normal repair mechanisms.”

• The Structural basis for the contribution of latent TGFβ binding protein to TGFβ latency and activation is published in on 05/08/26 DOI
• Image of microscope created with AI
• The study was funded by the Biotechnology and Biological Sciences Research Council and The Wellcome Trust.

That's the question addressed in the latest position paper from ����Vlog�ٷ�'s Dalton Nuclear Policy Group, which sets out practical opportunities for duty holders, regulators and government to build on the recommendations of the 2025 Nuclear Regulatory Task Force.

The paper, A radical reset: actionable opportunities from the UK nuclear regulatory review 2025, responds to a fundamental review of how the UK's nuclear sector is regulated. The review was launched by the UK government in 2025 as part of its plans to both expand nuclear energy generation and retain an effective nuclear deterrent, leading to the establishment of the Nuclear Regulatory Task Force.

The Task Force went on to publish a series of recommendations, aimed primarily at government but with some also directed towards industry. All of these were accepted in full by the government in early 2026 - however, little detail has been proposed to date on exactly how they might be implemented in practice.

The Dalton paper aims to fill that gap, putting forward a suite of practical opportunities which, if taken up, could deliver the more efficient and effective regulatory environment needed to underpin the UK's nuclear sector, without compromising on safety or security.

In developing the paper, the authors drew on input from within the Dalton Nuclear Institute's academic team - which includes individuals with extensive practical experience of policy, operations and regulation across the nuclear sector - as well as from a range of nuclear duty holders across both the civil and defence communities.

‘A once in a lifetime opportunity.’

Co-author Professor Francis Livens said the Task Force's review represented a rare chance to reshape the sector:

The authors hope the paper will be a useful input for those across the sector seeking to drive positive change.��

The paper is authored by:

• Dr William Bodel
• Professor Adrian Bull MBE, Hon FNucI
• Professor Gregg Butler
• Professor Francis Livens
• Dame Fiona Rayment DBE FREng FRSE.

Read the full paper:

Their discovery, published in the world leading journal on 04/08/26, centres on activated dendritic cells, a specialised population of immune cells that orchestrate the body’s attack on cancer.

To make the discovery, the researchers developed the first mouse models capable of specifically labelling or removing activated dendritic cells.

This allowed them to determine exactly how activated dendritic cells contribute to anti-cancer immunity.

The models are expected to accelerate research into activated dendritic cells across cancer, infections and autoimmune diseases.

Until now, scientists have struggled to understand precisely how activated dendritic cells contribute to anti-cancer immunity because suitable models did not exist.

Using the new models, the team showed that activated dendritic cells are indispensable for effective anti-cancer immune responses.

Without them, cancer-killing T cells could neither be efficiently activated nor maintain their strength once inside tumours.

As a result, both spontaneous immune control of cancer and the efficacy of immunotherapy were impaired.

First author Maria Koufakis said: “Modern immunotherapies rely on strong and coordinated immune responses, yet many people still do not benefit from these treatments.”

“If we can find ways to boost activated dendritic cells, we may be able to strengthen the immune system’s response to cancer and help more patients benefit from immunotherapy, including some whose cancers currently resist treatment.”

Senior author said: “Activated dendritic cells do not just launch the anti-tumour immune responses, they are also essential for sustaining them within the tumour itself.

This changes how we think about their role and opens up new opportunities to improve cancer immunotherapy.”

The work was funded by Cancer Research UK, with additional support from the European Molecular Biology Organization and the Italian Association for Cancer Research UK.

Research Information Manager at Cancer Research UK, Dr Marianne Baker, said: "Immunotherapies that harness our immune system to beat cancer are saving lives, but we don't yet understand why they work for some people and not others.

“The models developed as part of this study could help scientists unlock ways to boost these revolutionary treatments via dendritic cells, a type of immune cell.

“We need more research to get there, but this work could help to solve unanswered questions in cancer immunotherapy and beyond."

• Image: ��Ai-rendered 3D��representation of activated dendritic cell with a coral-coloured nucleus, highlighting the use of the new reporter model. The nucleus of the cells of interest has been labelled scarlet.

• CCR7⁺��activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity, published in Immunity is available . DOI DOI:��

The research, and funded by the NIHR Patient Safety Research Collaboration (PSRC): Greater Manchester, is the largest review of its kind and analysed evidence from 74 clinical trials conducted over 23 years.

The review found that digital patient safety tools in primary care can be beneficial - particularly when they combine multiple features, such as automated prescribing or missed test reports for doctors alongside digital communication tools for patients.

According to the findings, digital interventions currently being used in clinics:

• improved medication safety by 46% when compared to usual care, reducing high-risk prescribing and dosing errors
• improved non-medication safety processes by 77% when compared to usual care, including faster diagnostic checks and more timely laboratory monitoring
• reduced physical patient harm and adverse events by 17% when compared to usual care, helping to prevent unnecessary hospital admissions, asthma attacks and serious adverse drug reactions

The study highlights several specific digital technologies that were shown to enhance patient safety, improve communication and treatment decisions, and reduce diagnostic delays.

One of the digital tools highlighted is the UK-developed PINCER programme, which uses electronic health records to help GPs and pharmacists identify and prevent incorrect prescribing. The programme showed that digital systems can improve safety at scale while supporting better use of NHS resources.

The success of PINCER has also inspired new digital innovations, such as the , develoved through a partnership between researchers from the NIHR PSRC: Greater Manchester, NHS partners and industry. SMASH is a digital medication safety tool that helps clinicians identify and address medication risks more quickly and consistently. Early evaluation in Salford, for example, covering more than 235,000 patients across 43 GP practices, showed a 40% reduction in hazardous prescribing within 12 months.

By embedding evidence-based safety indicators into routine clinical practice, SMASH helps clinicians identify and address medication risks more quickly and consistently. Early evaluation in Salford, for example, covering more than 235,000 patients across 43 GP practices, showed a 40% reduction in hazardous prescribing within 12 months.

The systems that work best

Researchers found that the greatest improvements came from integrated systems that combined multiple features, such as clinical decision support tools, patient communication systems and audit and feedback mechanisms.

For example, where Clinical Decision Support Systems (CDSS) - which prompt GPs with real-time alerts about drug interactions or missing tests - were paired with Audit and Feedback (A&F) systems, which allow clinics to regularly review their safety data.

In addition, tools that featured patient-facing elements - such as automated text reminders or patient portals - had a positive impact on non-medication safety, making patients nearly 3 times more likely to receive timely investigations and follow-up care.

However, the review found that technology alone is not enough. More than 40% of the studies reported implementation barriers, including alert fatigue - where clinicians are overwhelmed by excessive computer pop-ups - and software that disrupted busy GP consultations. The most successful interventions were those that fitted naturally into existing clinical workflows and were supported by training, relationships and organisational engagement.

Lead researcher, Dr Jung Yin Tsang, from ����Vlog�ٷ�, said:

“Our research suggests that the future of safer care will not be built on software alone, but on how well digital tools work alongside patients, clinicians, pharmacists and healthcare teams.

"To unlock their full potential across the NHS, we must move away from isolated, complex software. Policymakers and developers must focus on intuitive, joined-up systems that fit naturally into a GP’s busy workday without adding to their administrative burden."

Professor Mike Lewis, NIHR Scientific Director for Innovation, said:

“This NIHR-funded evidence demonstrates how well-designed digital technologies can improve patient safety in everyday care. It highlights the importance of investing in robust research into digital technology so the NHS adopts the systems which are safe and proven to improve outcomes for patients and staff.”

Health and Social Care Minister Baroness Merron, said:

“This research shows the real difference that well-designed digital technology can make to patient safety, helping clinicians reduce medication errors, identify risks earlier and ensure patients receive timely care.

“As we deliver our 10-Year Health Plan, we are transforming the NHS through better use of technology, so staff have the tools they need to provide safer, more joined-up care closer to home. Research like this helps ensure we invest in digital innovations that deliver better outcomes for patients and support our workforce.

"By backing high-quality research and adopting technologies that are proven to work, we can build a modern NHS that is safer, more efficient and provides the highest quality care for every patient."

--

The paper Digital patient safety interventions in primary care: a systematic review and meta-analysis was published in BMC Medicine and is .

Read the full NIHR news story: .

When it is done well, in other words when your yogurt pots (polypropylene, PP) are sorted from your milk jugs (high density polyethylene), mechanical recycling is the most environmentally positive way to turn plastic waste into new products in a circular plastics economy, turning pots into pots and jugs into jugs.

However, poor sorting can lead to mixing polyolefins together, changing the way that the plastic degrades during the recycling process.

While well understood for polyethylene, the study, published in , focuses on what happens when PP is mixed with HDPE. Researchers found that contaminants act as stress aggregators, and that the phase separation caused by contamination weakens the material. While HDPE can tolerate a few percent contamination, even 1% of HDPE in PP alters the degradation mechanism.

The result of this contamination, even at this small scale, is a recyclate with radically altered physical properties, a change which impacts structure-property relationships and reduces the overall performance of the material, especially important in the context of their industrial reuse.

Researchers argue that while efforts have been made to normalise polymers based on processing history and end-use application, approaches like these only consider a limited number of material grades and do not represent the broad range of polyolefin grades and blends.

They suggest that cross-contamination needs better analytical tools that can serve as quality control in industrial processes, evidencing the need for better sortation in household and industrial recycling.

This paper was published in the journal: ChemCircularity

Full title: Measuring the impact of cross-contamination on quality in polyolefin blends

DOI:

Some of our most eye-catching items included our giant pencil and a graphene enforced crash helmet. One of our most popular activities gave children the opportunity to exfoliate graphite using adhesive tape, recreating the famous technique that led to the isolation of graphene. After viewing their samples under a microscope the children were able to take their graphene home! Visitors enjoyed learning how a material as seemingly ordinary as the graphite found in pencils can be peeled into sheets only a single atom thick.

Over the course of the day, we spoke to hundreds of visitors about the potential applications of graphene and 2D materials, including use in advanced electronics and sustainable technologies. The curiosity and enthusiasm shown by the children and adults alike highlighted the value of public engagement activities in helping researchers share their work beyond academia.��

The Universally Manchester Festival gave us the opportunity to develop our skills in communication and public engagement with a lay audience. Hopefully we inspired the next generation of material scientists!

Thank you to the University for hosting the event and to everyone who came to visit our stand. Seeing so much excitement for science reinforced the importance of outreach within the CDT, and we look forward to engaging with even more communities in the future.

The study was carried out in collaboration with the Australian Nuclear Science and Technology Organisation (ANSTO) and was made possible through the assistance of Emudu Trekkers and members of the Idu Mishmi community, the traditional custodians of the Dibang Valley. The research was funded by a Walters Kundert Fellowship from the Royal Geographical Society (UK).

This study provides the first dated glacial chronology for the Dri Valley in the remote eastern Himalayas, filling a major gap in understanding glacier evolution in one of the least-studied sectors of the Himalayas and providing an important benchmark for future studies of regional climate change.

Key findings

• The Dri Valley glacier reached almost 100 km in length, making it one of the largest glaciers yet documented in High Mountain Asia.
• It extended from altitudes of around 5,300 metres to as low as 1,300–1,500 metres above sea level, giving it one of the lowest known glacier termini in High Mountain Asia.
• The glacier was 80 km in length around 19,600 years ago.
• By around 12,000 years ago, the glacier had retreated to altitudes above 3,250 m and was less than 20 km long.
• Today, its largest surviving remnant is less than 5 km long.

Reconstructing the past Himalayan landscape

Researchers examined the landscape of the Dri Valley for geomorphic evidence left behind by the ancient glacier, including U-shaped valleys, moraines and distinctive bedrock features created by the movement of ice.

The research combines detailed field observations with satellite mapping and digital elevation models to build a picture of the former ice extent and identify locations where exposed rock could provide evidence of past glacier movements.

These features provide a record of how the glacier shaped the landscape as it advanced and retreated, but establishing when those changes occurred required highly sensitive dating techniques.

“The Dri Valley preserves an exceptional record of past glaciation, but until now we had no reliable way of placing these landforms into a timeline,” said Dr Shashank Nitundil of ����Vlog�ٷ�, who led the research.

Using rocks as natural clocks

The researchers collected 63 samples from boulders and exposed bedrock surfaces across the Dri Valley. This is the first application of cosmogenic nuclide dating on the southern slopes of the Himalayas east of Mount Everest.

The samples were analysed for cosmogenic radionuclides – rare isotopes produced in rocks exposed at the Earth's surface by cosmic rays.

The team focused on beryllium-10 (¹⁰Be), which accumulates in quartz-bearing rocks while they are exposed to cosmic radiation. When a glacier covers a rock surface, production of the isotope is effectively halted and eventually reset due to glacial erosion. When the ice retreats and the rock is exposed again, ¹⁰Be begins to accumulate. Measuring its concentration allows researchers to determine when the ice disappeared.

The measurements were carried out using accelerator mass spectrometry at the Australian Nuclear Science and Technology Organisation (ANSTO), allowing the team to detect the extremely small quantities of ¹⁰Be needed to establish the timing of past glacier change.

“The huge size of the former glacier in the Dri Valley hints at similar extensive ice cover in neighbouring valleys and the presence of one of the largest contiguous ice masses in the Himalayas. Until now little has been known about the extent, timing and palaeoclimatic significance of the former glaciers in this region and the exciting results of this research have been made possible because of a major international collaboration between the University of Manchester, ANSTO and local support from members of the Idu Mishmi community” said Professor Philip Hughes of ����Vlog�ٷ�, who co-supervised the research and has had long-term collaborations with Dr David Fink at ANSTO.

Understanding monsoon-driven glacier change

The Dri Valley sits within a region dominated by the Indian Summer Monsoon, which delivers some of the highest precipitation across the Himalayas, making it an important natural laboratory for understanding how monsoon-fed glaciers respond to climate change.

The study shows that abundant monsoon precipitation alone was not enough to sustain this giant glacier. Instead, its growth and retreat were shaped by the interplay between temperature, precipitation and topography.

The findings suggest that once temperatures rise above a critical threshold, increasing precipitation falls as rain rather than snow. This reduces glacier accumulation and, at the same time, can accelerate ice loss through melting meaning heavy precipitation does not necessarily protect these glaciers from warming.

The study adds to growing evidence that the response of Himalayan glaciers to climate change is not uniform. Glaciers in different parts of the mountain range are influenced by contrasting combinations of snowfall, temperature, elevation and seasonal climate patterns.

As well as being climatically significant, the Dri Valley and surrounding region form part of a recognised Himalayan biodiversity hotspot, adding further importance to understanding how its glaciers and the water resources they feed are likely to change.

Understanding how Himalayan glaciers responded to past climate change provides an important long-term benchmark for improving projections of how these glaciers may respond to continued global warming in the future.

Publication details

The paper was published in journal Quaternary Science Reviews. The international research team included Dr Shashank Nitundil, Dr Christopher Darvill, Prof Abi Stone, Dr David Fink, Prof Philip Hughes, Dr Matt Tomkins and Dr Krista Simon.

DOI:

The findings of the study, funded�� by the National Institute of Health and Care Research (NIHR) suggest the wraps may not be the best first-line option for patients receiving strong compression therapy.��

Venous leg ulcers affect thousands of people and can take months to heal, causing pain, reduced mobility and a significant burden on healthcare services.��

Strong compression is an important treatment for people with venous leg ulcers, to improve blood flow in the lower leg and support healing.��

It can be provided in different ways, including bandages systems that can have two or four layers, compression stockings that have two layers and adjustable compression wraps that fasten around the leg with Velcro-style straps.��

All these compression approaches aim to deliver the same level of compression but differ in how they are applied, how easy they are to use and how comfortable people find them.��

Wraps have become increasingly popular because they can be adjusted and, in some cases, self-applied by people with leg ulcers or those around them.�� However, there has been limited high-quality evidence comparing compression wraps with other commonly used strong compression treatments.��

The researchers carried out a large randomised controlled trial involving 637 adults receiving care at 33 mainly community sites across the UK.��

Participants were assigned to be offered either compression wraps, two-layer compression bandages, or established evidence-based compression treatments (four-layer bandages or two-layer compression stockings)��

The researchers found that ulcers healed more slowly in patients offered compression wraps than in those offered established evidence-based compression treatments.��

Patients receiving compression wraps also appeared to heal more slowly than those treated with two-layer compression bandages, although this difference was not statistically significant.��

The study found that two-layer compression bandages performed similarly to established evidence-based compression treatments.��

The findings provide some of the strongest evidence to date comparing commonly used compression therapies for venous leg ulcers.��

A separate companion process evaluation found patients liked compression wraps because they were comfortable, easy to adjust, and could be removed for showering,��

However, these same features may also mean that people are more likely to loosen or remove the wraps, potentially reducing the amount of therapeutic compression delivered and helping explain the slower healing observed in the trial.��

Together, the studies suggest compression wraps should not routinely be the first choice for most people with venous leg ulcers.��

However, they may still be appropriate for some patients where comfort, independence or self-management are particularly important, provided patients receive clear advice on maintaining effective compression.��

Jo Dumville, Professor of Applied Health Research from the University of Manchester said: “Venous leg ulcers can have a major impact people’s quality of life and place a significant burden on healthcare services, so it is important that health professionals have robust evidence to guide treatment decisions”.��

“Our study compared three commonly used strong compression approaches in a real-world NHS setting and suggested that�� that compression wraps do not improve healing times when compared with established evidence-based treatments.”��

Catherine Arundel, Senior Research Fellow at the University of York said: “While some uncertainty remains, these findings suggest that compression wraps are unlikely to offer a healing advantage as a first-line treatment”.��

“The results will help clinicians, patients and healthcare providers make informed decisions about the most appropriate therapies for managing venous leg ulcers."��

• The paper Compression therapies for venous leg ulcers: The VENous Ulcer Study 6 (VenUS 6), an open, multicentre, randomised clinical trial is published in PLOS Medicine
• The companion process evaluation Compression therapies for the treatment of venous leg ulcers: a mixed method process evaluation in a randomised controlled trial, VenUS6�� is published in Trials

Professor Mahima Swamy’s lab studies intestinal immunology, diet, infection, and immune-mediated bowel diseases (Coeliac and Crohn’s). The group particularly focuses on intraepithelial lymphocytes (IEL), a poorly characterised class of T cells residing within the intestinal epithelium, and their communication with epithelial cells.

Mahima joins the Becker from The University of Dundee, where she is a Programme Leader in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU). In 2016, Mahima established her own research group in the MRC PPU, supported from 2017 by a Wellcome Trust Sir Henry Dale Fellowship, and became an EMBO Young Investigator in 2022.

Originally from Bangalore, India, Mahima studied Biological Sciences and Biotechnology at BITS Pilani before completing her PhD at the Max-Planck Institute of Immunobiology in Freiburg, Germany, studying T-cell receptor biochemistry with Wolfgang Schamel. She then held postdoctoral positions with Adrian Hayday at CRUK's London Research Institute, researching intestinal immune surveillance, and with Doreen Cantrell at Dundee, uncovering roles for O-GlcNAc modification in T cell lymphomagenesis and development.

Mahima said: “I am very excited to be joining ����Vlog�ٷ� and the Lydia Becker Institute. I have always appreciated the amazing immunology research that happens at the Becker and loved the collegiate and friendly atmosphere whenever I have visited. With the recent award of the MRC Centre of Research Excellence in Exposome Immunology to the University, I think this is a great time to be joining and to be able to contribute to the great mucosal barrier research going on here.”

Commenting on the appointment, Professor Tracy Hussell, Director of the Lydia Becker Institute said: “I am thrilled that Mahima will be joining the Lydia Becker Institute at Manchester. Her fantastic research on intestinal immunity is a natural fit with our focus on barrier tissues and their interaction with environmental stressors.”

Sixty years after the 1966 World Cup final, the most famous football in England's history has been examined as never before. NXCT at ����Vlog�ٷ� and the National Football Museum have produced the first 3D X-ray scans of the Slazenger Challenge 4 Star used at Wembley on July 30, 1966 – rendering, in extraordinary detail, both its 25-panel hand-stitched leather exterior, and the degraded latex bladder sealed inside it since the day England won the World Cup.

It is a portrait of a vanished craft. Each Challenge 4 Star took two-and-a-half hours to stitch by hand at the Slazenger works in Horbury, near Wakefield, and had to meet strict specifications. 14 to 16 ounces in weight, 27 to 28 inches in circumference. The ball earned its place in the final by winning a blind test of more than 100 footballs at The FA's headquarters. The now iconic orange was not a stylistic flourish, but a practical stand-out effect for the monochrome television sets of 1966.

Set against the ball used in this month's 2026 World Cup final, the scans make sixty years of progress impossible to miss. The Trionda is built from four thermally bonded panels of polyurethan, polyester, viscose and synthetic rubber, and carries an inertial measurement unit sensor that tracks every contact and position change. In 1966, the technology was a needle and thread.

The ball's journey to its casing at the National Football Museum is just as fascinating as the final it was used in. After England's 4-2 win in front of some 97,000 spectators, Helmut Haller – who had scored the opening goal – carried it back to Germany, claiming tradition entitled the first scorer to keep it. It stayed there for 30 years, until a consortium of the Mirror Group, Virgin, and Eurostar bought it for £80,000 and repatriated it ahead of Euro '96. The initials on its surface belong to Uri Geller, who signed it for luck as a pre-tournament publicity stunt.

Today, the ball sits on permanent display in the 'England on the World Stage' section of the National Football Museum, alongside Hurst's hat-trick shirt and other objects from the final. The museum marks the anniversary on Thursday 30 July with a programme of talks from its Visitor Experience team on the 1966 tournament and the final itself.

Dr Matthew Lawson, who performed the scans in the NXCT, said: "X-rays are a fantastic tool to non-destructively see inside objects, this technique has been used a lot in cultural heritage previously but never to look inside such a nationally significant football!

"Although a football is mostly air on the inside, we were able to see the makeup of the leather panels, the stitching and the perished air bladder in amazing detail thanks to X-ray computed tomography. Everyone at the NXCT in the University of Manchester would like to thank the National Football Museum for this exciting opportunity to scan such an artefact and to hold it in our own hands!"

Tim Desmond, CEO of the National Football Museum, said: "This is the most famous football in the country and, until now, nobody had ever properly looked inside it. What the scans give us is a window into how the game was made in 1966, the materials, the methods, the craft of a ball stitched by hand in a Yorkshire factory. It's also a measure of just how far the technology has travelled to reach the Trionda of 2026.

"We're a museum committed to educating ourselves and others, and to translating objects behind glass into stories people can get inside. As such, my thanks go to the University of Manchester for their expertise and curiosity that have created such a brilliant insight for our visitors and beyond. If you haven't seen it already, come and witness a slice of history for yourself."